No, Avalara can be used for any combination of legislations. The online help gives details of the setup.
Within X3 help - How To - Distribution - Implement Sage Sales Tax - https://online-help.sageerpx3.com/erp/12/wp-static-content/whitepapers/en_US/negoce/Implement%20Sage%20Sales%20Tax/Content/How-to%20guides/Distribution/Implement%20Sage%20Sales%20Tax/T1_Introduction.htm